GIOSTAR REVIEWS

In the recent discovery of motor neuron diseases, scientists were able to convert cells isolated from skin, into neuronal cells without compromising their stamens. These promising findings are helpful in understanding some of the internal mechanism, that may have direct as well as indirect impact on ALS. So far, scientists could discover that stem cells play a major role in neuronal differentiation, which are being damaged in  ALS . However, lot of questions still need to be answered regarding internal molecular pathways, that are forcing these differentiations to take place. Amyotrophic Lateral Sclerosis, or ALS is a deadly neurodegenerative condition, associated with massively damaged motor neurons. Due to this damage, signaling cascade providing information from central nervous system to muscles is being halted; leading to the neuromuscular damage. The pathophysiology of the disease is often associated with locomotary issues, progressive deterioration of involuntary as well as

Stem cells therapy has been acknowledged to be a new medical boon, and many of us want to hear about the latest advancements and discoveries in stem cells and the science of regenerative medicine. Myriad of degenerative conditions have been harassing the mankind, mainly due to unavailability of concrete treatment pattern in the conventional way of medicine. For that matter, scientists all over the world are trying to explore inherent mechanism that is forcing stem cells to repair and regenerate. Stem cells are identified to be the naïve cells of our body, which are involved in defining the entire cellular system. Although, stem cells applications have been recently explored, since the year 1970’s blood stem cells are widely used to treat many blood related disorders, like leukemia, malignant diseases, etc. The treatment can now be categorized as approved therapy and is being beneficial to many patients, who have been suffering with variety of blood related disorders. Further

The World Health Organization has recorded a global data of 36 million people, who have been suffering with type 1 diabetes ; which definitely raise an alarming situation. Diabetes is an autoimmune disorder, wherein body’s own immune cells attack and destroy insulin producing islets cells, due to which, glucose metabolism is affected. This, in deed requires stringent monitoring of sugar level and lifelong dependency on external insulin administration. While so far, no successful treatment has been reported conventionally to completely cure the issue, stem cells transplantation has reported to show successful outcome in many clinical investigations. Further to which, diabetes if ignored for a longer period of time can give rise to multiple organ failure, due to constant exposure to the higher blood glucose. Stem cells are the naïve cells of human body, with the ability to differentiate into multiple cells types; upon passage through the cascade of signalling pathways. These cells