Stem Cell Treatment for Muscular Dystrophy at Ahmedabad in India

Through the recent publication, it has been quite evident that just by enhancing one’s breathing capacity; it is possible to limit breathing capacity of the person, suffering with DMD.

Duchenne Muscular Dystrophy is a genetic disorder with neuromuscular degeneration; in the later stage, the disorder may lead to gradual depletion of a respiratory power. The said, respiratory muscular dysfunction is a characterized assessment of DMD. The estimated prevalence rate of muscular dystrophies is almost 1 in 7000 male children between the age 5 to 24 years. It has been surveyed to be rapidly progressing neuromuscular, congenital disorder that is exclusively observed in male children. The disorder is typically characterized with muscular weakness, leading to the increased disability. There are various types of muscular dystrophies, which have variable degree of severity, age of onset and life expectancy.

Initial symptoms reported in patients with DMD are delayed walking, frequent falls, difficulty in running as well as climbing stairs. Children may have been noted with bulkier muscles around the area of calves, thighs and hips. In the later stage of the disorders, children are reported to be completely wheel chair bound, along with certain co-morbid complications like scoliosis, muscular contracture, etc.  Some patients have also reported to develop cardiomyopathies with enlarged heart chambers and thinner cardiac walls. The condition is thus associated with breathing problems and may get life threatening.

Convectional medical treatment involves administration of steroid hormones; however, it should be noted that long term administration of steroid although has proven to be very helpful in delaying disease progression, may prove to be fatal with multiple organ failure. Hence, there is an urgent demand for an alternative treatment, which can reverse disease manifestation and slow down the progression. In this regard, stem cells therapy has been identified to be the best alternative, readily available in the current situation.

Stem cells are identified to be the basic building blocks of the body, with the ability to differentiate into cells of different tissues. These cells are first noticed at the time of embryonic development, during the eight-celled stage of the embryo and are found to be totipotent in nature. Being totipotent they can be converted to any and all cells of the body and hence are capable to giving rise to entire human being outside the body. This tremendous potential of stem cells has been scientifically identified to be very helpful in reversing the disease states of our body.  As a matter of fact, descendants of these powerful totipotent stem cells are being stored in every adult organ of our body and are being used for normal wear and tear. These cells can possibly be isolated by technological advancements in a sterile condition and injected back in the body to allow them to be converted into tissue specific cells.

In case of genetic disorders, like DMD stem cells are initially thought to be of no use; however, gradual studies in the same perspective have allowed researchers to identify that these cells can be helpful in minimizing the damaging effects on muscles. They can provide muscular strength, regularize immune system and allow differentiation of neuronal cells. Medical experts also believe that individual with DMD should allow regular booster dosage of stem cells, to slow down the disease progression.

Thus, stem cells therapy can definitely be referred to be as the hope for millions of people, who have been suffering with almost incurable, debilitating muscular dystrophy.

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