Stem Cells Treatment for Diabetes
According to the recent advances, stem cells
generated in advance national US laboratory, in collaboration with
International Space Station, have exhibited to be promising advancements in
generating insulin producing beta cells, to be helpful as a potential treatment
for type 1 Diabetes. Scientists are further interested in finding ways to cure
silent sugar disease, through the application of regenerative science; either
by producing beta cells or by creating environment through stem cells that will
indirectly support the production of beta cells. In both the cases, stem cells are identified
to be as the lead players.
Diabetes is a devastating, autoimmune
metabolic disorder affecting millions of people in the world. It is being
categorically distinguished into two major types, 1 & 2; depending upon
their functional attributes. As in, type 1 diabetes is often associated with
aberrant destruction of insulin producing beta cells, causing sugar molecule to
accumulate in the blood, due to unavailability of its transporter to cell, the
hormone insulin. Whereas, type 2
diabetes, is
associated with insulin resistance due to which various important organs of the
body, fail to respond insulin action; adding up to the progressive decline in
the functional production of insulin, through beta cells. Through conventional
medication, the only treatment that is being offered to overcome the issue, is
steroidal anti-inflammatory medicines to reduce further loss of beta cells
and/or insulin, along with supportive sugar free diet to keep blood sugar
within its range.
However, since long researchers were
struggling to find an alternative, cost effective cellular solution as a
potential strategy to treat diabetes, whether type 1 as well as type 2.
Accordingly, they have developed a great interest in unlocking the mysteries of
diabetes through possible expansion as well as exploration of stem cells
therapies. It has been apparent that stem cells are an appropriately viable
option to reverse cellular damage, associated with a particular cell type.
Theoretically, stem cells have found to respond through molecular signals, in
the local environment through differentiation of desired beta cells.
Stem cells are the tiny master cells, with
the ability to differentiate into multiple cell types upon subjected through
proper signalling pathways. This potential ability of stem cells has been
exploited by the medical science to treat diabetes. These stem cells have been
found to be laying in their dormancy in different autologous tissues of the
body, which can be isolated and enriched in better numbers in a controlled
condition for preparing them to inject locally at the site of injury. It has
been evident through variety of experiments honouring autologous application of
stem cells to be effectively utilized for their differentiation into insulin
producing beta cells, regulating immune regulatory cells to avoid immune
destruction of self-tissues and further promote a favourable microenvironment
to stimulate residential stem cells for being active against
self-differentiation. In this regard, many clinical studies have been performed
to assess clinical safety and treatment efficacy of stem cells therapy for
diabetes in obtaining effective treatment outcome.
Although, more and more mechanism is on the
way to standardize effective treatment outcome for curing silent metabolic
disorders, like diabetes; with the current knowledge and technological
establishment, it has been found to be the best possible option.
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