Stem Cells Treatment for Stroke


Recent clinical trial conducted by investigators of Sandford’s University has proven the efficacy and feasibility of adult stem cells from human tissues; in restoration and functional modification of chronic stroke patients. Furthermore, the trial has suggested that all stroke patients, with the recent attack between six months to three years remained conscious under general light anaesthesia.

Stem cells are the natural super cells of human body, giving rise to muscles, fat, bone and tendons. Although, primary clinical investigation reported further that these stem cells don’t exhibit any tumorigenic properties by differentiating into unwanted cells and tissues. The technology has enabled easy isolation of stem cells from body’s own sources, such as bone marrow as well as adipose tissues; being isolated from body’s own sources, they did not pose any attributable side effects, neither did they link to any life threatening adverse effects, post procedure. The principal investigators of the trial were quite happy with the outcome, and confirmed that the improvement they could notice was statistically significant and clinically meaningful.

Stroke is being identified as the second leading cause of death worldwide, with each year nearly 8,00,000 people suffering with it. It has been as well reported that amongst the total reported cases, nearly 85% people are suffering with ischemic stroke, due to formation of blood clots in a blood vessel supplying oxygenated blood to the affected area. Remaining 15% patients are estimated to be suffering with haemorrhagic stroke, occurring due to rupture of blood vessels. Currently, no gold standard treatment is available, except for administration of some steroidal, anti-inflammatory medicines; offered to manage the issue. Accordingly, application of stem cells therapy can be clinically effective option with added advantage of safety and feasibility as evident through many clinical trials.

Many scientists have offered their candid acceptance for the use of autologous body sources, for therapeutic interventions; rather than switching over to artificially structured sources, considering their safety, feasibility and ethical acceptance. It would not be surprising to say that these autologous adult stem cells sources are being tried and tested for more than a decade, with a great available data for effective cell dose, route of administration, safety profile, etc. Although, stem cells intrinsic mechanism is still very vague; scientist could able to analyse their superficial foot prints; in order to optimize their clinical transplant regimen. Thus, with the current available knowledge scientists are claiming to have gained better understanding of their signalling pathways to establish respectable profile towards their multilineage differentiation. In this regard, a choice of route of delivery depends upon therapeutic indication and a local administration through intra-cerebral delivery; while it has been evident that intra-venous as well as intra-arterial injections.

Thus, the effective clinical outcome from bench to bedside approach are found to be very helpful in authenticating and validating further to practice bench to bedside approach for further development of neurorestorative stroke therapies. Although, still many of the questions are to be resolved, considering current scenario; stem cells therapy can be powerful treatment alternatives.  

Comments

Post a Comment

Popular posts from this blog

Stem Cells Treatment For Osteoarthritis Dream Come True of Pain Free Life

In recent years the science and technology has been working in collaboration to welcome state of the art alternative treatment for conventional medical practices; which are not been able to treat many diseases, such as diabetes, neurological indications as well as arthritis. Recently with the FDA approval announcement for stem cells therapy and their applications for arthritic issue; the innovative therapy can be applied in the treatment of various degenerative conditions such as degenerative arthritis, tendonitis, as well as many ligament diseases. Many people now days, are suffering with dangerous diseases like arthritis, joint pain, injuries, etc; adding more disturbances to the day to day functioning of life. For many of them, the only option seeming to be viable is to take synthetic hormonal supplements and/or drastic surgeries. However, these conventional instincts were not able to solve joint problem, additionally long term use of synthetic drugs as well as surgeries can ...
Read more

MOTOR NEURON DISEASE: THE MISSING LABYRINTH

Amyotrophic Lateral Sclerosis , also commonly known as the motor neuron disease or Lou Gehrig’s disease is a fatal neurological ailment, associated with progressive muscular atrophy, weakness and functional loss. Facts you should know about ALS It is estimated that at any given point of time, 1-10 out of 100000 people can be affected by ALS; and each day 15 new cases are being diagnosed. Statistics has suggested that after about every 90 minutes someone is being diagnosed with ALS. According to the database shared by ALS care, 93% of ALS patients are of Caucasian origin; and the average life expectancy of people with ALS is between 2-4 years, post diagnosis. Early diagnosis of ALS is quite tricky due to common initial symptoms and it may possibly take a year of so for the confirmed diagnosis of ALS. Studies have confirmed that individuals suffering with ALS tend to lose their strength and ability to move their arms, legs and bodies. Eventually the person has to b...
Read more

Stem Cells Treatment A Perfect Remedy For Osteoarthritis

Image
Osteoarthritis , commonly known as the degenerative joint disorder is a group of abnormalities related to the degeneration of all the major joints present in the human body. To date, more than 10 million people are suffering from the disorders, irrespective of their age and gender; the hardest sufferers being people above age 60. More technically, the disease has been divided into primary osteoarthritis, that is linked with the genetic factors and secondary osteoarthritis that can be linked up with the deformity, accidents or injuries. Symptoms associated with the conditions can be joint pain, tenderness, stiffness, etc. Osteoarthritis is an inflammatory condition of the weight bearing joints such as knee, wherein the protective cushions of the bones known to be cartilages are deteriorated due to their overuse. This in turn can expose bones to the outer shock and irritation; causing them to be swollen, painful and tender. There are no specific treatments available so far, w...
Read more