Stem Cells Treatment for Stroke


Recent clinical trial conducted by investigators of Sandford’s University has proven the efficacy and feasibility of adult stem cells from human tissues; in restoration and functional modification of chronic stroke patients. Furthermore, the trial has suggested that all stroke patients, with the recent attack between six months to three years remained conscious under general light anaesthesia.

Stem cells are the natural super cells of human body, giving rise to muscles, fat, bone and tendons. Although, primary clinical investigation reported further that these stem cells don’t exhibit any tumorigenic properties by differentiating into unwanted cells and tissues. The technology has enabled easy isolation of stem cells from body’s own sources, such as bone marrow as well as adipose tissues; being isolated from body’s own sources, they did not pose any attributable side effects, neither did they link to any life threatening adverse effects, post procedure. The principal investigators of the trial were quite happy with the outcome, and confirmed that the improvement they could notice was statistically significant and clinically meaningful.

Stroke is being identified as the second leading cause of death worldwide, with each year nearly 8,00,000 people suffering with it. It has been as well reported that amongst the total reported cases, nearly 85% people are suffering with ischemic stroke, due to formation of blood clots in a blood vessel supplying oxygenated blood to the affected area. Remaining 15% patients are estimated to be suffering with haemorrhagic stroke, occurring due to rupture of blood vessels. Currently, no gold standard treatment is available, except for administration of some steroidal, anti-inflammatory medicines; offered to manage the issue. Accordingly, application of stem cells therapy can be clinically effective option with added advantage of safety and feasibility as evident through many clinical trials.

Many scientists have offered their candid acceptance for the use of autologous body sources, for therapeutic interventions; rather than switching over to artificially structured sources, considering their safety, feasibility and ethical acceptance. It would not be surprising to say that these autologous adult stem cells sources are being tried and tested for more than a decade, with a great available data for effective cell dose, route of administration, safety profile, etc. Although, stem cells intrinsic mechanism is still very vague; scientist could able to analyse their superficial foot prints; in order to optimize their clinical transplant regimen. Thus, with the current available knowledge scientists are claiming to have gained better understanding of their signalling pathways to establish respectable profile towards their multilineage differentiation. In this regard, a choice of route of delivery depends upon therapeutic indication and a local administration through intra-cerebral delivery; while it has been evident that intra-venous as well as intra-arterial injections.

Thus, the effective clinical outcome from bench to bedside approach are found to be very helpful in authenticating and validating further to practice bench to bedside approach for further development of neurorestorative stroke therapies. Although, still many of the questions are to be resolved, considering current scenario; stem cells therapy can be powerful treatment alternatives.  

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