The Features and Significance of Mesenchymal Cells in Stem Cell Treatment

Stem Cell Treatment is based on the use of stem cells for treating different diseases. In this kind of treatment, specialized cells that have the ability to renew themselves by cell division are used. These cells can also differentiate to create multi-lineage stem cells. Primarily, stem cells falls under the categories of ESCs (embryonic stem cells), adult cells, and iPSCs (induced pluripotent cells). Out of these Mesenchymal cells have been attracting attention, as human mesenchymal cells are multipotent cells and non hematopoietic and features the ability of differentiating, which leads to the creation of mesodermal lineage like adipocytes, osteocytes, as well as chondrocytes and hepatocytes.

For the very first time, human mesenchymal cells were found in bone marrow, and at present researchers have been able to derive these cells from different tissues including amniotic fluid, dental tissues, adipose tissues, endometrium, and even umbilical cord. Researchers are now also able to culture these cells for a long time without any complaints of severe irregularities. What makes mesenchymal cells favorable for Stem Cell Treatment, is the immunomodulatory characteristics of mesenchymal cells. These cells comprise of immune receptors and also secrete cytokines, which aids in regulating microenvironment when introduced in host tissues.

Secretion of molecules, which are anti-inflammatory and multilineage potential of mesenchymal cells, makes them feasible for Stem Cell Therapy, as these makes Stem Cell Treatment even more effective. Several studies have highlighted the benefits that mesenchymal cells renders when used in Stem Cell Therapy for treating chronic disorders. Clinical trials have also reflected similar positive results, making these cells a favorite of researchers for developing safer and more effective Stem Cell Therapy. Major studies based on mesenchymal cells, whether these are isolated from adults or embryos, have given a platform for further development and materialization of improve therapeutic technology for self-repairing of cells.


When it comes to application of mesenchymal cells in Stem Cell Treatment, these can be mobilized and activated when required, but in some cases like injury to muscles, the efficiency of these cells is a little slow. Presently, researchers are also looking for ways of enhancing the tissue repairing capability of mesenchymal cells. Several tests for finding out the efficiency of these cells in curing autoimmune diseases is also underway, and hopeful outcomes have given a push to the efforts of developing an effective Stem Cell Therapy for treating autoimmune diseases. These have been tested for treating conditions such as multiple sclerosis, Crohn’s disease, systemic sclerosis, etc. 

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